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KMID : 0388220140210050236
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Journal of the Korean Rheumatism Association
2014 Volume.21 No. 5 p.236 ~ p.240
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The Clinical Significance of Anti-cyclic Citrullinated Peptide Antibodies in Juvenile Rheumatoid Arthritis
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Kang Min
Sohn Tae-Young
Kim Sung-Hye
Lee Hae-Ran
Kang Hee-Jung
Kim Kwang-Nam
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Abstract
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Objective. The aim of this study was to determine the clinical significance of anti-cyclic citrullinated peptide (anti-CCP) an-tibody in juvenile rheumatoid arthritis (JRA).
Methods. Sera for anti-CCP assay were obtained from 142 pa-tients with arthralgia in our hospital during the period be-tween November 2010 and October 2011. On the basis of medi-cal records, 83 patients with JRA were designated to the study group, and 59 patients with arthralgia but were treated as transient arthritis to the control group. The values of anti-CCP were then analyzed retrospectively. We used the enzyme linked immunosorbent assay (ELISA) for detecting anti-CCP.
Results. Positive anti-CCP values were found in the sera of 11 patients with JRA (13.3%), one patient presented with pau-ciarticular JRA and the others with polyarticular JRA. There was a statistically significant difference in the anti-CCP values between the JRA group and the control group. However, pa-tients with systemic JRA and arthralgia without JRA had no anti-CCP. Especially, 10 out of 14 (71.4%) patients with RF-positive polyarticular JRA had anti-CCP. In addition, the rate of positive anti-CCP was significantly higher in patients with polyarticular JRA than in the control group.
Conclusion. We expect that the presence of anti-CCP may help to evaluate the severity of diseases in patients with JRA. Anti-CCP can be an important biomarker for making early in-tensive therapeutic decision in patients with polyarticular JRA, which might have more severe course and longer disease duration.
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KEYWORD
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Juvenile rheumatoid arthritis, Polyarticular, Cyclic citrullinated peptide
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